• Users Online: 306
  • Print this page
  • Email this page
Year : 2022  |  Volume : 14  |  Issue : 4  |  Page : 231-237

Antioxidant and inflammatory cytokines regulatory actions of fresh snail and seawater gastropods extracts

1 Department of Pharmaceutics, Government College of Pharmacy, Ratnagiri, Affiliated to Mumbai University, Mumbai, Maharashtra, India
2 Department of Pharmacognosy and Natural Product, Government College of Pharmacy, Affiliated to Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, Maharashtra, India

Correspondence Address:
Deepak Prakash Pawar
Government Polytechnic Campus, Thiba Road, Ratnagiri - 415 612, Maharashtra
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ajprhc.ajprhc_77_22

Rights and Permissions

Context: Mollusca also termed mollusks. These are unsegmented, bilateral animals. Freshwater and seawater gastropods are considered rich source of bioactive molecules that possesses various therapeutic potential. Aim: The present work aimed to investigate the antioxidant, wound healing, and anti-inflammatory effects along with the regulation of inflammatory protein at the cellular level by apple snail (freshwater gastropod) and tibia shell (seawater gastropod) extract. Materials and Methods: The mass of freshwater and seawater gastropods was macerated in water. Results: The aqueous extract of apple snail exhibited the highest 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity and 2,2'-azinobis-(3-ethylbenzothiazoline)-6-sulphonic acid (ABTS) activity at 85.62% and 73.35% at 10 mg/ml, whereas the aqueous extract of seawater gastropod exhibited the highest DPPH radical scavenging activity and ABTS activity 83.53% and 76.14% at 1 mg/ml. Marine water snail aqueous extract and freshwater snail aqueous extract, each of 250 mg/kg showed 83% and 67.14% inhibition of paw edema, respectively. The cell viability study was performed by MTT assay and both the extracts showed cell viability above 97%. Both samples (freshwater snail extract and seawater gastropod extract) have good anti-inflammatory effects as they lower the concentration of tumor necrosis factor-alpha (pro-inflammatory cytokines) and increase interleukin-10 (anti-inflammatory cytokines). Conclusion: The present work concluded that the extracts of seawater gastropods were found to be more effective as an antioxidant and anti-inflammatory agent.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded36    
    Comments [Add]    

Recommend this journal